Diabetes mellitus is a prevalent endocrine disease characterized by hyperglycemia resulting from insufficient insulin secretion or insulin resistance. It is one of the top ten leading causes of death on a global scale. The study aimed to evaluate the safety and efficacy of intensive insulin therapy for patients with type 1 diabetes mellitus in Jordan. It was an observational study conducted at Prince Hamza Hospital. The study included participants under the age of 18 who had been diagnosed with type 1 diabetes for at least 6 months and had no kidney disease. The study duration was 24 weeks. Data were collected by accessing patient profiles and extracting relevant information from medical records and laboratory results. Hyperglycemic and hypoglycemic symptoms were also recorded. HbA1c levels were measured before and after the transition to intensive insulin therapy. The sample size was determined to be 153 patients based on previous studies. Statistical analysis was performed using SPSS software. Descriptive statistics and tests such as paired t-tests and chi-square tests were used to analyze the data. Logistic regression analysis was conducted to identify factors associated with better glucose control and higher risk of hypoglycemia. The results demonstrate significant improvements in the intensive therapy group compared to the conventional therapy group. The proportion of hyperglycemic symptoms was considerably reduced in the intensive therapy group. Notable advancements in glucose management were observed, as indicated by a decrease in mean HbA1c levels and an increase in mean body weight in the intensive therapy group. The symptoms of hypoactivity were also significantly diminished in the intensive therapy group. Laboratory results revealed significant differences between the two therapy groups in pH, creatinine, chloride, and calcium levels. Additionally, specific gravity, urine character, and glucose positivity in urine analysis exhibited significant distinctions. These findings underscore the efficacy of intensive therapy in managing hyperglycemic symptoms, improving glucose control, and influencing various laboratory and urine analysis parameters when compared to conventional therapy in type I diabetes mellitus