This study reports the development and evaluation of controlled release Ibuprofen-matrix tablets. Matrix tablets weighing 600mg were fabricated by hot melt granulation method and direct compression of the granules containing Ibuprofen (200 mg) with PEG & PVAc the tablets were evaluated for physical properties, in-vitro swelling behavior, in-vitro release studies and compatibility studies. The rate release of Ibuprofen was dependent on concentration of PVAc in the formulation. Varying PVAc concentration from 2 to 10% in the formulation revealed that in 8hrs, tablets containing 10% w/w PVAc released about 70% of the initial Ibuprofen content compared to almost 98% of Ibuprofen released from tablets containing 2% w/w PVAc. Results of in-vitro swelling study indicate that ibuprofen with PEG6000/PVAc 8% exhibited a considerable swelling index. The results of differential scanning calorimetry (DSC) studies showed that Ibuprofen formed a simple mixture with PEG. Results of Fourier transform infrared spectroscopy (FTIR) study revealed that the principle peaks of drug are intact in the formulations. Drug excipients interactions were not observed and this indicates that the drug was compatible with the formulation components. Follows analysis of release mechanism using various models available, release of Ibuprofen from matrix tablets was dominated by polymers diffusion-controlled mechanism at least for the first 5hrs. Thereafter, the release mechanisms become more complicated due to change of tablet integrity, such as erosion of polymer matrix. Therefore, data fitted to Korsmeyers - Peppas equation indicated an Anomalous non-fickian transport suggesting that the drug release is mainly diffusion- erosion mechanism. In conclusion, controlled release Ibuprofen matrix tablets with desired drug release rate can be fabricated by various formulation variables. The drug release mechanism was found to be anomalous or non-fickian type and controlled by diffusion through the swollen matrix. The effect of experimental variables are discussed in relation to diffusional- models