Background: Heart failure affecting many people with a profound impact on the well-being of patients most of whom become depressed hence, deteriorating their quality of life with the majority of patients may having disabilities due to the nature of the disease. Social support plays an essential role in the management of depression with this aspect not studied in this group of people in Jordan. .Aim: The current study aims to assess the prevalence of depression among heart failure (HF) patients in Jordan, identify demographic, psychosocial, and medical predictors of depression, evaluate the role of social support systems, and examine the impact of depression on health outcomes in this population. Methodology: A quantitative, cross-sectional survey design was employed, gathering data from 155 heart failure patients from Princess Basma Hospital and AL Bashir Hospital in Jordan using a structured questionnaire. The questionnaire included three sections: demographic data, the Cardiac Depression Scale (CDS), and the Multidimensional Scale of Perceived Social Support (MSPSS). The CDS, consisting of 26 items, measured depressive symptoms, while the MSPSS, a 12-item scale, assessed perceived social support from family, friends, and significant others. Results: The study reveals a moderate prevalence of depression among heart failure (HF) patients in Jordan, with a mean Cardiac Depression Scale score of 3.04. Several demographic and psychosocial factors, such as age, gender, income, marital status, and social support from family, friends, and significant others, significantly predict depression. Social support, particularly from friends (Beta = -0.55), plays a crucial role in mitigating depressive symptoms, improving emotional stability. Depression adversely affects health outcomes by increasing uncertainty about health, leading to poorer physical well-being and lower quality of life. Significant differences in depression levels were noted across demographic variables, with older, lower-income, unemployed, or single individuals experiencing higher depression rates. Conclusion: This study underscores the importance of social support in managing depression among HF patients and provides a basis for targeted interventions to enhance social support networks. Keywords: Heart failure, Depression, Family support, Friends support, Others support