The main aim of this research is to explore the correlation between the hospitalisation for ischemic heart disease (IHD) patients and their associated medications. The specific objectives are to explore the following: rate of hospitalisation for IHD stratified by diagnosis, rate of hospitalisation for IHD stratified by age and gender, and change in the rate of dispensing of IHD medicines. We conducted an ecological study during the period 1999 - 2019. Hospital admission data for patients from all age groups were extracted from the Hospital Episode Statistics database in England and the Patient Episode Database for Wales. Data on prescriptions of IHD medications were extracted from the Prescription Cost Analysis database from 2004 to 2019. Rates of hospital admission with their 95% confidence intervals (CIs) were calculated using the number of IHD admissions for each age group divided by the mid-year population of the same age group of the same year. Ischemic heart disease medication prescription rates were calculated using the number of IHD medication prescriptions divided by the total mid-year population during the same year. The Chi-squared test was used to assess the difference between the admission rates in 1999 and 2019 and the difference between IHD medication prescription rates in 2004 and 2019. The trend in hospital admissions for IHD was assessed using a Poisson model. The correlation between hospital admission rates for IHD and its related medication prescribing rates were assessed using the Pearson correlation coefficient. Our study detected a significant increase in the rate of cardiovascular disease (CVD) medications prescription in England and Wales, representing a rise in CVD medications prescription rate of by 41.8% with a mean increase of 2.8% per year during the past 15 years. This increase was connected with a reduction in the IHD hospital admission rate: by 15.4% with a mean decrease of 1.02% per year during the past 15 years, and by 5% with a mean decrease of 0.25% per year during the past two decades in England and Wales. Conclusion: The rate of hospitalisation due to IHD has decreased in England and Wales during the past two decades. This decrease could be explained partly by the increase in the CVD medication prescription rate. Other likely reasons for the decreased rate of IHD-related hospital admissions are the decrease in IHD incidence and improved IHD treatments.