This study is designed to evaluate the use of bentonite to develop and optimize sustained release tablets by granulation method. The tablets were prepared using different binders then tested for their pharmcopeal requirements. Also, a HPLC method was developed to assess the release pattern of alogliptin from the tablets. FTIR, DSC and powder-XRD were used to evaluate the compatibility between the drug and bentonite. The results showed that the tablets comply with their compendial requirements and no interaction between the drug and the excipient. Furthermore, the release profile revealed sustained release of aloglepitin from the tablets prepared with aid of hydroxypropyl methyl cellulose (HPMC) as a binder. The data fitting showed that diffusion from the tablets followed Fickian model. However, it could be possible to formulate successfully sustained release tablets of aloglpitin using bentonite as an excipient. The formulated tablets complied with pharmacopeial requirements. The developed tablets using bentonite by granulation are good candidate for further in vivo evaluation.