Background: Coronary artery diseases are increasingly prevalent in Jordan and worldwide. Patients widely undergo coronary artery bypass grafting (CABG), an open-hart surgical procedure, for the restoration of healthy cardiac function, but this procedure can be a challenge physically and mentally. Educational programs are developed to help patients overcome these challenges. Purpose: The study aims to assess both knowledge, and quality of life (QoL) of coronary artery disease (CAD) patients' before and after a cardiac educational program and one month after CABG surgery, as well as determine their association with socio-demographic and health-related characteristics. Methodology: This study employed a pre-and-post one-group quasi-experimental design that was conducted for the period March 2022 to May 2022. A non-probability convenience sample of 50 adult coronary artery disease patients who had undergone CABG surgery in a public/teaching hospital in Jordan was recruited. The participants were tested for knowledge regarding their illness, using Auxilia's 2018-structured instrument, before and after attending a cardiac educational program., and were assessed for their QoL health indicators, using the SF-36 instrument, before attending the same educational program and one month after undergoing CABG surgery. Results: The mean knowledge score increased significantly after attending the program (p = .000). All QoL domain scores have also significantly improved after attending the program (p < 0.05), except for pain. Before attending the program, there were significant differences between participants' knowledge scores based on age, educational level, and marital status (p < 0.05)., these significant differences disappeared after the program. In addition, this study participants significantly varied in some of the QoL domain scores based on age, educational level, occupation, and marital status (p < 0.05)., most of these significant differences disappeared after the program. Conclusion: Coronary artery disease patients have generally low levels of knowledge of their illness and QoL. The implementation of a cardiac educational program improves patients' knowledge of their illness and enhances all the domains of the quality of their life except pain. Therefore, the adoption of such a program is recommended though other effective strategies are needed to assist patients in managing their pain. Key Words: Cardiac Educational Program, CABG, Knowledge, Quality of Life, Jordan.