Background Cerebrovascular accidents/ Stroke are debilitating diseases that has a significant association with neuropsychiatric disorders including depression, anxiety and stress. Post-stroke psychological difficulties, including depression, anxiety, and stress, are significant health issues among Jordanians who suffer from stroke and require an urgent national response and immediate intervention. Purpose This study aimed to evaluate the effect of creative art therapy on the levels of depression, anxiety, and stress among patients with stroke in Jordan. Methods The study participants were patients with stroke aged 44-70 years who attended hospitals affiliated with the Jordanian Ministry of Health. A group of pretest-posttest designs were used over two weeks using the purposive sampling technique. Result The current study sample included 85 patients with stroke, with a mean age of 54.42 (standard deviation = ±6.1) years. Also 67.6% of the study participants were females, 40.0% were males, 60.0%. More than 70% of the study participants reported different levels of depression, of which 17.6%, 28.2%, and 68% reported extremely severe, severe, and moderate levels of anxiety, respectively. Approximately 90% reported severe-to-moderate levels of stress. There was a significantly positive relationship between depression and age (r = 0.448**; p < 0.001); anxiety and age, sex, and family income before intervention (r = ?0.638**, p < 0.01; r = 0.219**, p < 0.01; and r = 0.217*, p < 0.05, respectively); and stress and age and sex (r = 0.587**, p < 0.01 and r = 0.399**, p < 0.01, respectively). The results revealed a significant difference between the levels of depression, anxiety, and stress among the study participants before and after the creative art therapy sessions and intervention for depression, anxiety, and stress (t = 37.98, p < 0.001; t = 20.59, p < 0.001; and t = 35.52, p < 0.001, respectively). Creative art therapy resulted in a statistically significant improvement in depression, anxiety, and stress levels. Conclusion These results confirm that creative art therapy can be a complementary therapy to increase well-being; reduce the levels of depression, anxiety, and stress; and help patients with stroke express their feelings and emotions.