When people decide to treat themselves by medication without going to a physician for a prescription, that is called self-medication (SM). This study aims to detect the prevalence rate of SM among ophthalmic patients in Jordan. The study applied as a cross-sectional study design, using a questionnaire tool that was filled out by 1,009 ophthalmic patients. The prevalence rate of participants practising SM for ophthalmic conditions was 21.0%. The most common reason that motivated these patients to self-medicate was getting medical recommendations from a pharmacist or optician (55.7%), followed by failure to believe in the severity of the symptoms, so they thought that they did not need a doctor to treat their eyes (34.4%). Eye symptoms included redness (69.3%), eye itching (61.3%), and feeling a burning sensation (38.7%). The 24-30-year-old age group was more likely to practice SM (p<0.05). Other patients who had previously undergone ophthalmic surgery and were currently wearing contact lenses were less susceptible to SM practice (p<0.05). Self-medication, especially in the field of eye diseases, is considered a double-edged sword that may be harmful but could also have benefits, provided that it is practised correctly.