The base isolator mechanism is one of the most efficient methods in decreasing the effect of earthquake force transmitted to the building. This system is created for earthquake protection by increasing the frequency of the structure away from the elemental frequency of seismic excitation and fixed base structure. In this study, the dynamic behavior of short, medium, and high rise multistory reinforced concrete buildings will be investigated with rubber base isolation resisting system, shear wall system, and moment resisting frame, using the finite element method; with the extended Three-Dimensional Analysis of Building System (ETABS). The approximate analytical study consists of (27 analytical) models to calculate the responses of the building such as the floor displacement and drift ratios. The reinforced concrete building consisting of, 5, 10, and 20 floors. The loads, geometry, support conditions, and material properties to perform the analysis are assumed. In this research, the buildings were considered to be under the effect of forced vibration due different types of dynamic loads such as earthquake and wind loads using the response spectrum charts. The responses for the different buildings having different damping systems was presented and compared. The following conclusions were reached based on the results of this study. Due to the rigidity of the shear wall systems, it is considered the best system for the high rise buildings, to control the lateral displacements and drifts of the building, lead rubber Base isolation has its best performance in the case of medium-rise buildings due to its flexibility in controlling floor displacement, drifts, and in reducing the base shear and the overturning moments, where the moment-resistant structure systems were the best for low-rise buildings because of their simplicity and also because of the low seismic loads affecting them.