Introduction: This study used bentonite in developing and optimizing a controlled release multiparticulate drug delivery system of Ibuprofen (Ibu). Different granules were prepared using different binders as well as using water only without binder. The flowability of granules was evaluated before compression. Materials and method: The compatibility between the different components of granules was evaluated using Fourier Transform Infrared Spectroscopy (FTIR). Then, the prepared tablets of these granules were evaluated regarding their mechanical strength and weight uniformity. The dissolution behavior was established in 0.1N HCl medium and phosphate buffer 7.2 pH using HPLC method. Results and discussion: The granules showed good flowability. Also, FTIR-spectra did not show any interaction between the different components. Furthermore, the prepared tablets complied with their compendia requirements. The tablets released Ibu at constant rate for 16 hr. at least. This behavior was altered after subjecting the tablets to acidic media. However, protecting the tablet by enteric coating using Eudragit could maintain their sustained release behavior. Conclusion: Bentonite was successfully used in preparing sustained release tablets containing Ibu. However, the enteric coating is important to maintain the gel structure of bentonite by shielding it from the destructive effect of acidic gastric juice.