تاريخ مجلس الدراسات العليا

2022-06-29

اسم الطالب

محمود جمال مختار مختار

ملخص الرسالة

Transdermal Drug Delivery System (TDDS) now a day is one of the most important methods rout to deliver certain drugs in a safe efficient, sustained manner ,is to achieve the acceptance of the patient. Microemulsions (MEs) are known to be good drug delivery systems for transdermal application. The droplet size and rheological properties play a vital role in the quality of MEs. develop a new micro emulsion for the application of transdermal LD HC1, improve their bioavailability and lower side effect Non-ionic surfactants were used to formulate MEs containing Loratadine HCl (LD HCl) in this study . The MEs were characterized for their rheological, poly disparity index (PDI) and droplet size properties. Furthermore, the flux of LD HCl was evaluated by Franz diffusion cell in vitro over 24h where the penetrated amount of LD HCl estimated using validated high performance liquid chromatography (HPLC) method. The in vivo bio availabilities of encapsulated LD HCl in MEs were studied in rats. The results showed that the MEs complies with their colloidal characteristics, transparency, and have ideal viscosity. Moreover, the highest achieved flux value of MEs containing LD HCl through the skin using Franz diffusion cell was 0.0753 and 0.0724 mg/cm2 hr for ME F7 and ME F13, respectively. The in vivo results showed a maximum plasma level of 345.152 and 328.164 ug/ml after 12 hrs for MEs F7 and MEs F13 respectively .and a maximum plasma level 50.135 ug/ml at 4.5 hr for tested oral suspension containing LD HCl . The tested non-ionic MEs containing LD HCl can be used as an excellent carrier and promising formulation for LD HCl transdermal delivery.