Page 119 - أبحاث كلية الصيدلة 2016-2020

2020 Publications

AAPS PharmSciTech
volume 21, 126 (2020)

A Novel Technique to Improve Drug Loading Capacity of Fast/Extended Release
Orally Dissolving Films with Potential for Paediatric and Geriatric Drug Delivery

Gailany I. Ouda, Eman Z. Dahmash, Hamad Alyami & Affiong Iyire
Orally dissolving films (ODFs) have received much attention as potential oral drug delivery systems
for paediatric and geriatric patients, particularly those suffering from dysphagia. With their unique
properties and advantages, the technology offers improved patient compliance and wider acceptability,
eliminates the fear of choking, enables ease of administration and offers dosing convenience, without
the requirement of water. However, adequate drug loading remains a challenge. The aim of this study
was to mechanistically design and evaluate fast and extended release ODF formulations with high
drug loading capacity, displaying good physicochemical and mechanical properties, as a potential
dosage form for paediatric and geriatric use employing a slightly soluble model drug—ibuprofen.
Different polymers (0.6–10% HPMC, 0.6–1.5% guar gum), plasticisers (0.1–0.5% glycerine, 0.1%
sorbitol) and processing conditions (40–60°C drying temperatures, 8–16 h drying times) were
investigated to produce films using the solvent casting method. Molecular compatibility was assessed
using TGA, XRD and FTIR whereas film topography was assessed using SEM. Maximum ibuprofen
load in single films was 20.7 mg/film (54.4%) and released 100% drug content in 5 min, while triple
layered ibuprofen-loaded films contained 62.2 mg/film and released 100% drug release in 1 h. The
ODFs demonstrated good disintegration time using low volume artificial saliva media and high dosage
from uniformity. This study provides a mechanistic insight to the design and evaluation of fast and
extended release ODFs with high drug loading, suitable for administration to paediatric and
geriatric patients.
https://link.springer.com/article/10.1208/s12249-020-01665-5

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