Page 43 - أبحاث كلية الصيدلة 2016-2020

2017 Publications

AAPS PharmSciTech

Development of a Sustained Antiplaque and Antimicrobial Chewing Gum
of a Decapeptide

Abeer M. Al-Ghananeem, Kai P. Leung, Jabar Faraj, and Patrick P. DeLuca

The objective of this paper was to design a chewing gum formulation delivery system
in situations where typical dental hygiene practice is not practical. Thus, an analog of
decapeptide KSL (KSL-W), known to possess antimicrobial and antiplaque activity,
was incorporated into a chewing gum formulation containing cetylpyridinium chloride
(CPC). The effect of the excipients, xylitol, and peppermint oil on active ingredients in
vitro release was also assessed. Gum formulations were prepared with different
excipient parameters, including heating xylitol and gum base at 65 or 85°C, using
ground and unground xylitol, and the addition of 1.5, 3, and 7% peppermint oil, to
determine the effect of these changes on the in vitro release of KSL-W and CPC using a
chewing machine. The antimicrobial and antiplaque activities of solutions released from
chewed gum formulation as well as prepared standard solutions with different
concentrations were tested against placebo. The optimal temperature to avoid
crystallization of xylitol during preparation was 65°C. Grinding xylitol to 104.5 μm
improved release of active ingredients as compared to commercially unground xylitol.
Peppermint oil had opposite effects on release of KSL-W and CPC. Peppermint oil at
1.5% was determined to be suitable (91 and 88% of KSL-W and CPC released,
respectively, after 40 min). The gum formulation illustrated good sustained release of
KSL-W and CPC with antibacterial and antiplaque activities after chewing. An
effective antimicrobial and antiplaque chewing gum formulation was developed. This
formulation has the potential to overcome oral hygiene issues in those unable to follow
normal dental protocols.

https://pubmed.ncbi.nlm.nih.gov/28070851/

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