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2018 Publications

Neurophysiolog
Vol. 50, No. 3, June, 2018

Effects of Vitamin E on the Synthesis of Phospholipids and Brain Functions in Old
Rats

Loay Kh. M. Hassouneh

We examined the effects of supplementation of old rats with vitamin E (alpha-
tocopherol, αTPh, acetate) on phospholopid (PL) metabolism in the brain and cognitive
functions of these animals. Intragastric administration of αTPh to 24-month-old rats for
14 days resulted in a noticeable increase in the level of newly synthesized
phosphatidylserine (PS) in the hippocampus of experimental animals, as compared with
control rats. At the same time, there was a decrease in the [14C] phosphatidylcholine
(PC) content in the hippocampus of experimental rats vs. controls. Changes in the PL
levels observed in the hippocampus of experimental animals due to αTPh
administration were associated with an increased number of active avoidances and a
decreased latent period of these events within acquisition of the respective conditioned
reflex in a shuttle box. The data obtained provide evidence that αTPh is a potent
modulator of PL metabolism in the hippocampus and functions of the latter at ol d age.

https://link.springer.com/article/10.1007/s11062-018-9733-3

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