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2019 Publications

Pharmacoepidemiol Drug Saf.
2019;28(S2):5-586

Prevalence of chronic kidney diseases in patients with diabetes mellitus in the
Middle East: A systematic review and metaanalysis

Abdallah Y. Naser; Hassan Alwafi
Background: Diabetes mellitus is a major risk factor for chronic kidney diseases
(CKDs). Chronic kidney diseases increase the risk of morbidity and mortality as a result
of cardiovascular complications and may progress to end‐stage renal diseases. The
prevalence of CKDs in patients with diabetes mellitus in the Middle East region is
unclear.
Objectives: This review aims to review the existing literature on the prevalence of
CKDs in patients with diabetes mellitus in the Middle East region.
Methods: Medline, EMBASE and Cochrane Review databases were searched for
relevant studies up to January 2019. The search strategy was conducted using both
keywords and MeSH terms. Following PRISMA guidelines, two reviewers
independently screened articles, extracted data and assessed the quality of the included
studies. Randomized controlled trials (RCTs) and observational studies including
patients from all age groups, and any study design related to the prevalence of CKDs in
patients with diabetes mellitus were included in the review. Pooled estimate for the
prevalence of CKDs in patients with diabetes were calculated using random effect
models with 95% confidence intervals (CI).
Results: A total of 489 citations were identified of which only 3 studies matched our
inclusion criteria and were included in this review. The three studies were of an
observational study design (two retrospective and one prospective study), covering a
total of 57,122 patients with type 2 diabetes mellitus aged 25 years and above. The
pooled estimate of the prevalence of CKDs in patients with diabetes mellitus was
25.4% (95% CI, 8.1–42.8).
Conclusions: The findings of this review highlighted that there is a lack of studies on
the prevalence of CKDs in patients with diabetes mellitus in the Middle East region.
Further epidemiological studies are required to investigate the prevalence of CKDs
among patients with diabetes mellitus.

https://onlinelibrary.wiley.com/doi/full/10.1002/pds.4864

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