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2019 Publications
Indian Journal of Chemistry
Vol. 58B, May 2019, pp. 587-593
Synthesis, molecular docking and evaluation of hypolipidemic activities of
novel benzophenonecarboxamide derivatives
Manal Al-Najdawi, Bilal Al-Jaidi,Qosay A l-Balas, Haifa'aOdetallah, Tariq Al-Qirim,
GhassanShattat, Yusuf Al-Hiarif
Fibrates are well known hypolipidemic agents and act by activating Peroxisome
Proliferator-Activated Receptors (PPAR); this family of receptors is the main regulator
or fatty acid metabolism. In the present study, a total of six novel
benzophenonecarboxamide derivatives (3-6, 9 and 10) have been synthesized and
evaluated for their hypolipidemic activity. Interestingly, compounds 4 and 6 show
promising hypolipidemic activity and lower the level of TG by 71% and LDL-C by
26% and 29% respectively. Further, molecular docking studies have been carried out to
gain insight into the binding interactions of all the newly synthesized compounds inside
the PPARα receptor and the results are in consonance with the biological activity. The
encouraging in vivohypolipidemic activity of compounds 4 and 6 by lowering LDL-C
levels as well as enhancing HDL-C indicates that these compounds can serve as
promising lead compounds for further investigations for the development of novel
hypolipidemic agents.
http://nopr.niscair.res.in/handle/123456789/47296
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