The users of prosthetics and orthotics services come from all walks of life and have physical impairments or functional limitations. These conditions can be caused by a variety of factors including:

• noncommunicable diseases like diabetes, stroke, cancer, and peripheral vascular disease,
• communicable diseases such as tuberculosis, poliomyelitis, and Buruli ulcers,
• injuries from falls, road traffic and industrial accidents, natural disasters, war and conflicts,
• degenerative changes in the spine, hip, knee, foot, ankle, or upper limbs, congenital anomalies or limb deficiencies, and cerebral palsy.